Article
Crystal structure of peroxide stress regulator from Streptococcus pyogenes provides functional insights into the mechanism of oxidative stress sensing.
The Journal of biological chemistry - 21 Jun 2013
Makthal Nishanth, Rastegari Sheila, Sanson Misu, Ma Zhen, Olsen Randall J, Helmann John D, Musser James M, Kumaraswami Muthiah
Abstract excerpt
Regulation of oxidative stress responses by the peroxide stress regulator (PerR) is critical for the in vivo fitness and virulence of group A Streptococcus. To elucidate the molecular mechanism of DNA binding, peroxide sensing, and gene regulation by PerR, we performed biochemical and structural characterization of PerR. Sequence-specific DNA binding by PerR does not require regulatory metal occupancy. However,...
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