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A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence

1 May 2001

Abstract excerpt

Restricted iron availability is a major obstacle to growth and survival of pathogenic bacteria during infection. In contrast to Gram-negative pathogens, little is known about how Gram-positive pathogens obtain this essential metal. We have identified two Streptococcus pneumoniae genetic loci, pit1 and pit2, encoding homologues of ABC iron transporters that are required for iron uptake by this organism. S....

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PMID: 11359564
DOI: 10.1046/j.1365-2958.2001.02414.x

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