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Article

Peroxide responsive regulator PerR of group A Streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress.

PloS one - 1 Jan 2013

Wang Chih-Hung, Chiang-Ni Chuan, Kuo Hsin-Tzu, Zheng Po-Xing, Tsou Chih-Cheng, Wang Shuying, Tsai Pei-Jane, Chuang Woei-Jer, Lin Yee-Shin, Liu Ching-Chuan, Wu Jiunn-Jong

Abstract excerpt

The peroxide regulator (PerR) is a ferric uptake repressor-like protein, which is involved in adaptation to oxidative stress and iron homeostasis in group A streptococcus. A perR mutant is attenuated in surviving in human blood, colonization of the pharynx, and resistance to phagocytic clearance, indicating that the PerR regulon affects both host environment adaptation and immune escape. Sda1 is a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24312597
DOI: 10.1371/journal.pone.0081882
PMCID: PMC3849366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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