Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence

28 Mar 2017

Abstract excerpt

ABSTRACT Group A Streptococcus (GAS) is a human-only pathogen that causes a spectrum of disease conditions. Given its survival in inflamed lesions, the ability to sense and overcome oxidative stress is critical for GAS pathogenesis. PerR senses oxidative stress and coordinates the regulation of genes involved in GAS antioxidant defenses. In this study, we investigated the role of PerR-controlled metal transporter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal and Maternal Infections
Share to Streptococcal Infections and Treatments
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28348051
DOI: 10.1128/iai.00091-17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus VirulencePMID 28348051Read ↗

The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes.Semantic proximity Read ↗

Manganese Homeostasis in Group A Streptococcus Is Critical for Resistance to Oxidative Stress and VirulenceSemantic proximity Read ↗

Cellular management of Zinc in group B <i>Streptococcus</i> supports bacterial resistance against metal intoxication and promotes disseminated infectionSemantic proximity Read ↗

A PerR-regulated metal transporter (PmtA) is an interface between oxidative stress and metal homeostasis in Streptococcus pyogenes.Semantic proximity Read ↗

PmtA functions as a ferrous iron and cobalt efflux pump in Streptococcus suisSemantic proximity Read ↗

PerR-Regulated Manganese Import Contributes to Oxidative Stress Defense in Streptococcus suisSemantic proximity Read ↗

Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.Semantic proximity Read ↗

Streptococcus pyogenes Hijacks Host Glutathione for Growth and Innate Immune EvasionSemantic proximity Read ↗

The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniaeSemantic proximity Read ↗

The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of <i>Leptospira interrogans</i>Semantic proximity Read ↗

Differential Regulation of Iron- and Manganese-Specific MtsABC and Heme-Specific HtsABC Transporters by the Metalloregulator MtsR of Group A <i>Streptococcus</i>Semantic proximity Read ↗

Identification of zinc-dependent mechanisms used by Group B <i>Streptococcus</i> to overcome calprotectin-mediated stressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.