Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus

4 Sept 2008

Abstract excerpt

The peroxide response transcriptional regulator, PerR, is thought to contribute to virulence of group A Streptococcus (GAS); however, the specific mechanism through which it enhances adaptation for survival in the human host remains unknown. Here, we identify a critical role of PerR-regulated gene expression in GAS phagocytosis resistance and in virulence during pharyngeal infection. Deletion of perR in M-type 3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimicrobial Resistance in Staphylococcus
Share to Infective Endocarditis Diagnosis and Management
Share to Streptococcal Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18773116
DOI: 10.1371/journal.ppat.1000145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A StreptococcusPMID 18773116Read ↗

The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes.Semantic proximity Read ↗

Peroxide responsive regulator PerR of group A Streptococcus is required for the expression of phage-associated DNase Sda1 under oxidative stress.Semantic proximity Read ↗

Genome-Wide Analysis of Group A Streptococci Reveals a Mutation That Modulates Global Phenotype and Disease SpecificitySemantic proximity Read ↗

Genome-wide identification of genes required for fitness of group A Streptococcus in human blood.Semantic proximity Read ↗

Transcriptional regulator PerA influences biofilm-associated, platelet binding, and metabolic gene expression in Enterococcus faecalis.Semantic proximity Read ↗

Genome-wide protective response used by group A <i>Streptococcus</i> to evade destruction by human polymorphonuclear leukocytesSemantic proximity Read ↗

Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes.Semantic proximity Read ↗

A PerR-regulated metal transporter (PmtA) is an interface between oxidative stress and metal homeostasis in Streptococcus pyogenes.Semantic proximity Read ↗

Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus VirulenceSemantic proximity Read ↗

PolA1, a putative DNA polymerase I, is coexpressed with PerR and contributes to peroxide stress defenses of group A Streptococcus.Semantic proximity Read ↗

Effects of the ERES pathogenicity region regulator Ralp3 on Streptococcus pyogenes serotype M49 virulence factor expression.Semantic proximity Read ↗

Staphylococcus aureus senses human neutrophils via PerR to coordinate the expression of the toxin LukABSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.