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Article

Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats.

Neurotoxicity research - 1 Jan 2004

Kalivas Peter W, Szumlinski Karen K, Worley Paul

Abstract excerpt

Addiction to cocaine results from changes in brain function arising from a combination of pharmacology, environmental circumstances, as well as genetic vulnerability. One change is a reduction in Homer protein in the nucleus accumbens. In this report we summarize the behavioral and neurochemical effects of Homer2 gene deletion in mice and compare this with the effects of chronic cocaine treatment in rats. It was...

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PMID: 15545022
DOI: 10.1007/BF03033313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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