Article
Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants.
Developmental neuroscience - 1 Jan 1998
Drago J, Padungchaichot P, Accili D, Fuchs S
Abstract excerpt
Recent advances in molecular biology have resulted in a number of genetically manipulated mice with defined changes at dopamine receptor and the dopamine transporter (DAT) loci. Mice with targeted mutations at the D1 receptor (D1R) are growth-retarded and show downregulated expression of dynorphin and substance P. Behavioral assessment indicates that mutants have deficiencies in spatial learning and initiating...
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