Interphase fluorescence <i>in situ</i> hybridization with an <i>IGH</i> probe is important in the evaluation of patients with a clinical diagnosis of chronic lymphocytic leukaemia

Abstract excerpt

Translocations involving IGH are common in some lymphoid malignancies but are believed to be rare in chronic lymphocytic leukaemia (CLL). To study the clinical utility of fluorescence in situ hybridization (FISH) for IGH translocations, we reviewed 1032 patients with a presumptive diagnosis of CLL. Seventy-six (7%) patients had IGH translocations. Pathology and clinical data were available for the 24 patients...

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