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Article

Distinct Patterns of Colocalization of the CCND1 and CMYC Genes With Their Potential Translocation Partner IGH at Successive Stages of B-Cell Differentiation.

Journal of cellular biochemistry - 1 Jul 2016

Sklyar Ilya, Iarovaia Olga V, Gavrilov Alexey A, Pichugin Andrey, Germini Diego, Tsfasman Tatiana, Caron Gersende, Fest Thierry, Lipinski Marc, Razin Sergey V, Vassetzky Yegor S

Abstract excerpt

The immunoglobulin heavy chain (IGH) locus is submitted to intra-chromosomal DNA breakages and rearrangements during normal B cell differentiation that create a risk for illegitimate inter-chromosomal translocations leading to a variety of B-cell malignancies. In most Burkitt's and Mantle Cell lymphomas, specific chromosomal translocations juxtapose the IGH locus with a CMYC or Cyclin D1 (CCND1) gene,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin D1

Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Share to Genetic Loci

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Share to In Situ Hybridization, Fluorescence

Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 26873538
DOI: 10.1002/jcb.25516

Genes

IGH
CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Distinct Patterns of Colocalization of the CCND1 and CMYC Genes With Their Potential Translocation Partner IGH at Successive Stages of B-Cell Differentiation.PMID 26873538Read ↗

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