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Article

Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila.

Nature neuroscience - 1 Dec 2004

Rolls Melissa M, Doe Chris Q

Abstract excerpt

Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons. Here we examined their mutant and overexpression phenotypes in Drosophila melanogaster. We found that mutants neurons had normal axon and dendrite morphology and remodeled axons correctly in metamorphosis, and that overexpression...

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Identifiers

PMID: 15543144
DOI: 10.1038/nn1346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila.PMID 15543144Read ↗

Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia.Semantic proximity Read ↗

Bazooka mediates secondary axon morphology in Drosophila brain lineages.Semantic proximity Read ↗

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.Semantic proximity Read ↗

Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons.Semantic proximity Read ↗

Rac GTPases control axon growth, guidance and branching.Semantic proximity Read ↗

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.Semantic proximity Read ↗

Kinase-activity-independent functions of atypical protein kinase C in Drosophila.Semantic proximity Read ↗

Requirement for Par-6 and Bazooka in Drosophila border cell migration.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants.Semantic proximity Read ↗

Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Semantic proximity Read ↗

APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.Semantic proximity Read ↗

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