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Article

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.

Proceedings of the National Academy of Sciences of the United States of America - 30 May 2006

Chen Y M, Wang Q J, Hu H S, Yu P C, Zhu J, Drewes G, Piwnica-Worms H, Luo Z G

Abstract excerpt

The PAR-3/PAR-6/atypical PKC (aPKC) complex is required for axon-dendrite specification of hippocampal neurons. However, the downstream effectors of this complex are not well defined. In this article, we report a role for microtubule affinity-regulating kinase (MARK)/PAR-1 in axon-dendrite specification. Knocking down MARK2 expression with small interfering RNAs induced formation of multiple axon-like neurites...

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Identifiers

PMID: 16717194
DOI: 10.1073/pnas.0509955103
PMCID: PMC1482526

Genes

MARK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.PMID 16717194Read ↗

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