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Article

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.

Cell - 10 Jan 2003

Shi Song-Hai, Jan Lily Yeh, Jan Yuh-Nung

Abstract excerpt

How a neuron becomes polarized remains an outstanding question. Here, we report that selection of the future axon among neurites of a cultured hippocampal neuron requires the activity of growth factor receptor tyrosine kinase, phosphatidylinositol 3-kinase (PI 3-kinase), as well as atypical protein kinase C (aPKC). The PI 3-kinase activity, highly localized to the tip of the newly specified axon of stage 3...

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Identifiers

PMID: 12526794
DOI: 10.1016/s0092-8674(02)01249-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.PMID 12526794Read ↗

APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.Semantic proximity Read ↗

RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC.Semantic proximity Read ↗

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity.Semantic proximity Read ↗

Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.Semantic proximity Read ↗

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity.Semantic proximity Read ↗

Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons.Semantic proximity Read ↗

Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero.Semantic proximity Read ↗

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiationSemantic proximity Read ↗

The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase.Semantic proximity Read ↗

Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Mammalian SAD kinases are required for neuronal polarization.Semantic proximity Read ↗

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