Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.

doi:10.1016/j.cub.2010.01.065

Article

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.

Current biology : CB - 13 Apr 2010

Krahn Michael P, Klopfenstein Dieter R, Fischer Nannette, Wodarz Andreas

Abstract excerpt

Cell polarity in higher animals is controlled by evolutionarily conserved protein complexes, which localize to the cytocortex in a polarized manner. The PAR-3/PAR-6/atypical protein kinase C (aPKC) complex is the first to become asymmetrically localized, and it controls the localization of additional complexes functioning further downstream in the regulation of cell polarity. The first component of the...

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Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.

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Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.

Abstract excerpt

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