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Article

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation

15 Feb 2002

Abstract excerpt

Alterations of the proto-oncogene MLL (mixed lineage leukemia) are characteristic for a high proportion of acute leukemias, especially those occurring in infants. The activation of MLL is achieved either by an internal tandem duplication of 5' MLL exons or by chromosomal translocations that create chimeric proteins with the N-terminus of MLL fused to a variety of different partner proteins. A domain of MLL with...

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PMID: 11842107
DOI: 10.1093/nar/30.4.958

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Source receipt: pubmed, retrieved 7 Sept 2026.

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