Article
Ski negatively regulates erythroid differentiation through its interaction with GATA1.
Molecular and cellular biology - 1 Dec 2004
Ueki Nobuhide, Zhang Leiqing, Hayman Michael J
Abstract excerpt
The Ski oncoprotein dramatically affects cell growth, differentiation, and/or survival. Recently, Ski was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. These divergent roles of Ski are probably dependent on Ski's capacity to bind multiple partners with disparate functions. In particular, Ski alters the growth and...
Topics
- Animals
- Blotting, Western
- COS Cells
- Cell Differentiation
- Cell Nucleus
- Cell Proliferation
- Chromatin Immunoprecipitation
- DNA
- DNA-Binding Proteins
- Erythrocytes
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Gene Expression Regulation