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Article

Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).

The Journal of biological chemistry - 10 Apr 2015

Siatecka Miroslawa, Soni Shefali, Planutis Antanas, Bieker James J

Abstract excerpt

Erythroid Kruppel-like factor (EKLF or KLF1) is a transcription factor crucial for red cell development that is directly involved in regulation of a large number of erythroid genes. EKLF serves mostly as an activator of expression of these genes; however, it can act also as a repressor. Here, we present evidence that EKLF interacts with proteins from the PIAS (protein inhibitor of activated STAT) family that...

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Identifiers

PMID: 25713074
DOI: 10.1074/jbc.M114.610246
PMCID: PMC4392289

Genes

PIAS3
KLF1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).PMID 25713074Read ↗

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Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation.Semantic proximity Read ↗

Krüppel-Like Factor 1: A Pivotal Gene Regulator in ErythropoiesisSemantic proximity Read ↗

Erythroid Kruppel‐like factor (EKLF) is recruited to the <i>γ</i>‐<i>globin</i> gene promoter as a co‐activator and is required for <i>γ</i>‐<i>globin</i> gene induction by short‐chain fatty acid derivativesSemantic proximity Read ↗

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Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingSemantic proximity Read ↗

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Direct competition between DNA binding factors highlights the role of Krüppel-like Factor 1 in the erythroid/megakaryocyte switch.Semantic proximity Read ↗

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EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiationSemantic proximity Read ↗

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