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Article

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.

Genes & development - 15 Feb 1999

Nomura T, Khan M M, Kaul S C, Dong H D, Wadhwa R, Colmenares C, Kohno I, Ishii S

Abstract excerpt

The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRbeta). The oncogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10049357
DOI: 10.1101/gad.13.4.412
PMCID: PMC316468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor.PMID 10049357Read ↗

Signal-dependent N-CoR requirement for repression by the Ski oncoprotein.Semantic proximity Read ↗

The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice.Semantic proximity Read ↗

Direct Interaction of Ski with Either Smad3 or Smad4 Is Necessary and Sufficient for Ski-mediated Repression of Transforming Growth Factor-β SignalingSemantic proximity Read ↗

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 PhosphorylationSemantic proximity Read ↗

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.Semantic proximity Read ↗

Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.Semantic proximity Read ↗

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Ski negatively regulates erythroid differentiation through its interaction with GATA1.Semantic proximity Read ↗

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Transforming Growth Factor-β/SMAD Target Gene SKIL Is Negatively Regulated by the Transcriptional Cofactor Complex SNON-SMAD4Semantic proximity Read ↗

Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene.Semantic proximity Read ↗

JMJD2A Is a Novel N-CoR-Interacting Protein and Is Involved in Repression of the Human Transcription Factor Achaete Scute-Like Homologue 2 (ASCL2/Hash2)Semantic proximity Read ↗

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