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Article

Direct Interaction of Ski with Either Smad3 or Smad4 Is Necessary and Sufficient for Ski-mediated Repression of Transforming Growth Factor-β Signaling

1 Aug 2003

Abstract excerpt

The oncoprotein Ski represses transforming growth factor (TGF)-beta signaling in an N-CoR-independent manner. However, the molecular mechanism(s) underlying this event has not been elucidated. Here, we identify an additional domain in Ski that mediates interaction with Smad3 which is important for this repression. This domain is distinct from the previously reported N-terminal Smad3 binding domain in Ski....

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PMID: 12857746
DOI: 10.1074/jbc.c300276200

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