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Article

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

Haematologica - 1 Apr 2014

Singbrant Sofie, Wall Meaghan, Moody Jennifer, Karlsson Göran, Chalk Alistair M, Liddicoat Brian, Russell Megan R, Walkley Carl R, Karlsson Stefan

Abstract excerpt

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a...

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Source

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Identifiers

PMID: 24415629
DOI: 10.3324/haematol.2013.093971
PMCID: PMC3971074

Genes

SKI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.PMID 24415629Read ↗

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