Article
Signal-dependent N-CoR requirement for repression by the Ski oncoprotein.
The Journal of biological chemistry - 4 Jul 2003
Ueki Nobuhide, Hayman Michael J
Abstract excerpt
The oncoprotein Ski represses transforming growth factor-beta (TGF-beta) and nuclear receptor signaling. To achieve this, Ski has been proposed to recruit the corepressor N-CoR to either the TGF-beta-regulated Smad transcription factors or nuclear receptors. Here we define the role of the Ski/N-CoR interaction in Ski-mediated repression of TGF-beta and vitamin D signaling. We show that Ski can negatively regulate...
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