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Article

Repression of endogenous Smad7 by Ski.

The Journal of biological chemistry - 2 Jul 2004

Denissova Natalia G, Liu Fang

Abstract excerpt

The Ski protein has been proposed to serve as a corepressor for Smad4 to maintain a transforming growth factor-beta (TGF-beta)-responsive promoter at a repressed, basal level. However, there have been no reports so far that it indeed acts on a natural promoter. We have previously cloned the human Smad7 promoter and shown that it contains the 8-base pair palindromic Smad-binding element (SBE) necessary for...

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Identifiers

PMID: 15128733
DOI: 10.1074/jbc.M404961200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Repression of endogenous Smad7 by Ski.PMID 15128733Read ↗

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 PhosphorylationSemantic proximity Read ↗

Transforming Growth Factor-β/SMAD Target Gene SKIL Is Negatively Regulated by the Transcriptional Cofactor Complex SNON-SMAD4Semantic proximity Read ↗

Direct Interaction of Ski with Either Smad3 or Smad4 Is Necessary and Sufficient for Ski-mediated Repression of Transforming Growth Factor-β SignalingSemantic proximity Read ↗

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.Semantic proximity Read ↗

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.Semantic proximity Read ↗

Signal-dependent N-CoR requirement for repression by the Ski oncoprotein.Semantic proximity Read ↗

Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and diseaseSemantic proximity Read ↗

Ski and SnoN: negative regulators of TGF-β signalingSemantic proximity Read ↗

Participation of Smad2, Smad3, and Smad4 in Transforming Growth Factor β (TGF-β)-induced Activation of Smad7Semantic proximity Read ↗

Regulation of Smad7 Promoter by Direct Association with Smad3 and Smad4Semantic proximity Read ↗

Repression of TGF-β signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasisSemantic proximity Read ↗

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β SignalingSemantic proximity Read ↗

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