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Article

The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 Phosphorylation

1 Jul 2003

Abstract excerpt

The phosphorylation of Smad2 and Smad3 by the transforming growth factor (TGF)-beta-activated receptor kinases and their subsequent heterodimerization with Smad4 and translocation to the nucleus form the basis for a model how Smad proteins work to transmit TGF-beta signals. The transcriptional activity of Smad2-Smad4 or Smad3-Smad4 complexes can be limited by the corepressor Ski, which is believed to interact...

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PMID: 12732634
DOI: 10.1074/jbc.m304459200

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The Oncoprotein Ski Acts as an Antagonist of Transforming Growth Factor-β Signaling by Suppressing Smad2 PhosphorylationPMID 12732634Read ↗

Direct Interaction of Ski with Either Smad3 or Smad4 Is Necessary and Sufficient for Ski-mediated Repression of Transforming Growth Factor-β SignalingSemantic proximity Read ↗

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Transforming Growth Factor-β/SMAD Target Gene SKIL Is Negatively Regulated by the Transcriptional Cofactor Complex SNON-SMAD4Semantic proximity Read ↗

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Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.Semantic proximity Read ↗

Signal-dependent N-CoR requirement for repression by the Ski oncoprotein.Semantic proximity Read ↗

Ski and SnoN: negative regulators of TGF-β signalingSemantic proximity Read ↗

Repression of TGF-β signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasisSemantic proximity Read ↗

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