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Article

Developmental control of cAMP-induced Ca2+-influx by cGMP: influx is delayed and reduced in a cGMP-phosphodiesterase D deficient mutant of Dictyostelium discoideum.

Cell calcium - 1 Jan 2005

Lusche Daniel F, Malchow D

Abstract excerpt

It was previously shown that cGMP enhances cAMP-induced Ca2+-influx in Dictyostelium discoideum. This finding is based on experiments done with strains defective in cGMP-hydrolysis, the streamer F cells. In this work, we show that these chemically mutagenized cells display different properties in their cAMP-induced light-scattering response and cAMP-induced Ca2+-influx compared with a cGMP-phosphodiesterase...

Topics

3',5'-Cyclic-GMP Phosphodiesterases
Animals
Arachidonic Acid
Calcium
Calcium Channels
Calcium Signaling
Cell Membrane
Cyclic AMP
Cyclic GMP
Cyclic Nucleotide Phosphodiesterases, Type 5
Dictyostelium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Dose-Response Relationship, Drug

Extracellular Fluid

Mutation

Photic Stimulation

Up-Regulation

Source

Identifiers

PMID: 15541464
DOI: 10.1016/j.ceca.2004.06.005

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