Article
cAMP controls cytosolic Ca2+ levels in Dictyostelium discoideum.
BMC cell biology - 7 Mar 2005
Lusche Daniel F, Bezares-Roder Karen, Happle Kathrin, Schlatterer Christina
Abstract excerpt
BACKGROUND: Differentiating Dictyostelium discoideum amoebae respond upon cAMP-stimulation with an increase in the cytosolic free Ca2+ concentration ([Ca2+]i) that is composed of liberation of stored Ca2+ and extracellular Ca2+-influx. In this study we investigated whether intracellular cAMP is involved in the control of [Ca2+]i. RESULTS: We analyzed Ca2+-fluxes in a mutant that is devoid of the main...
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