Article
A model for cAMP-mediated cGMP response in Dictyostelium discoideum.
Molecular biology of the cell - 1 May 1994
Valkema R, Van Haastert P J
Abstract excerpt
In Dictyostelium discoideum extracellular cyclic AMP (cAMP), as shown by previous studies, induces a transient accumulation of intracellular cyclic guanosine-5'-monophosphate (cGMP), which peaks at 10 s and recovers basal levels at 30 s after stimulation, even with persistent cAMP stimulation. Ad...
Topics
- 3',5'-Cyclic-GMP Phosphodiesterases
- Adaptation, Physiological
- Animals
- Calcium
- Cell Membrane
- Computer Simulation
- Cyclic AMP
- Cyclic GMP
- Dictyostelium
- Extracellular Space
- Guanylate Cyclase
- Inositol Phosphates
- Intracellular Fluid
- Kinetics
- Models, Biological
- Mutation
- Receptors, Cyclic AMP