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Article

A modified yeast assay used on archival samples of localized prostate cancer tissue improves the detection of p53 abnormalities and increases their predictive value.

BJU international - 1 Nov 2004

Shi Xu-Bao, Gandour-Edwards Regina, Beckett Laurel A, Deitch Arline D, de Vere White Ralph W

Abstract excerpt

OBJECTIVE: To determine the frequency and predictive value of p53 mutations in localized prostate cancer, comparing the accuracy of detection using immunohistochemistry (IHC) with a modified yeast assay, on archival tissue samples. MATERIALS AND METHODS: Prostate cancer tissue was obtained from 98 patients who had >/= 2 years of clinical follow-up after radical prostatectomy. DNA sequencing was used to verify the...

Topics

Adult
Aged
Biological Assay
Genes, p53
Humans
Immunohistochemistry
Male
Middle Aged
Mutation
Predictive Value of Tests
Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensitivity and Specificity

Yeasts

Source

Identifiers

PMID: 15541116
DOI: 10.1111/j.1464-410X.2004.05093.x

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