Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complex functions of mutant p53 alleles from human prostate cancer.

The Prostate - 1 Apr 2002

Shi Xu-Bao, Nesslinger Nancy J, Deitch Arline D, Gumerlock Paul H, deVere White Ralph W

Abstract excerpt

BACKGROUND: Few studies have used multiple assays to examine the functionality of mutant p53 in prostate cancer (CaP). We employed seven functional assays to study 16 representative mutant p53 alleles, six from localized and ten from metastatic CaP. METHODS: Yeast assays were employed to determine loss of function (LOF), partial function (PF), and dominant-negative status. Assays using p53-null Saos2 cells were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Cyclins
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Prostatic Neoplasms

Share to S Phase

Share to Transcriptional Activation

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 11920959
DOI: 10.1002/pros.10072

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complex functions of mutant p53 alleles from human prostate cancer.PMID 11920959Read ↗

Application of a yeast assay to detect functional p53 mutations in archival prostate cancer tissue.Semantic proximity Read ↗

Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cells.Semantic proximity Read ↗

Mutant p53 elicits context-dependent pro-tumorigenic phenotypes.Semantic proximity Read ↗

A modified yeast assay used on archival samples of localized prostate cancer tissue improves the detection of p53 abnormalities and increases their predictive value.Semantic proximity Read ↗

Transcriptional functionality of germ line p53 mutants influences cancer phenotype.Semantic proximity Read ↗

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3Semantic proximity Read ↗

Androgen-independent growth of LNCaP prostate cancer cells is mediated by gain-of-function mutant p53.Semantic proximity Read ↗

p53 oncogene mutations in three human prostate cancer cell lines.Semantic proximity Read ↗

The DU145 human prostate carcinoma cell line harbors a temperature-sensitive allele of p53.Semantic proximity Read ↗

Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.Semantic proximity Read ↗

Very frequent p53 mutations in metastatic prostate carcinoma and in matched primary tumors.Semantic proximity Read ↗

p53 mutations in prostate cancer bone metastases suggest that selected p53 mutants in the primary site define foci with metastatic potential.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.