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Article

Tumor protein expression of the DNA repair gene BRCA1 and lethal prostate cancer.

Carcinogenesis - 14 Jul 2020

Stopsack Konrad H, Gerke Travis, Zareba Piotr, Pettersson Andreas, Chowdhury Dipanjan, Ebot Ericka M, Flavin Richard, Finn Stephen, Kantoff Philip W, Stampfer Meir J, Loda Massimo, Fiorentino Michelangelo, Mucci Lorelei A

Abstract excerpt

DNA repair genes are commonly altered in metastatic prostate cancer, but BRCA1 mutations are rare. Preliminary studies suggest that higher tumor expression of the BRCA1 protein may be associated with worse prognosis. We undertook a prospective study among men with prostate cancer in the Health Professionals Follow-up Study and evaluated BRCA1 via immunohistochemical staining on tissue microarrays. BRCA1 was...

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Identifiers

PMID: 32556091
DOI: 10.1093/carcin/bgaa061
PMCID: PMC7359768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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