Application of a yeast assay to detect functional p53 mutations in archival prostate cancer tissue.

doi:10.1089/108497802320970262

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Article

Application of a yeast assay to detect functional p53 mutations in archival prostate cancer tissue.

Cancer biotherapy & radiopharmaceuticals - 1 Dec 2002

Shi Xu-Bao, Di Mauro Stephen M, Highshaw Ralph, Deitch Arline D, Evans Christopher P, Gumerlock Paul H, deVere White Ralph W

Abstract excerpt

Detection and functional evaluation of mutant p53 alleles using a yeast assay could yield significant information for predicting the prognosis of patients with prostate cancer (CaP). Since the current version of this yeast assay is not applicable to archival tissues, we developed a modified assay for use on formalin-fixed, paraffin-embedded tissue and have applied it to the study of patient samples. Using this...

Topics

Genes, p53
Humans
Male
Mutation
Polymorphism, Single-Stranded Conformational
Prostatic Neoplasms
Yeasts

Source

Open in PubMed

Identifiers

PMID: 12537669
DOI: 10.1089/108497802320970262

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