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Article

Evaluation of the Prognostic Role of TP53 Gene Mutations in Prostate Cancer Outcome: A Systematic Review and Meta-Analysis.

Clinical genitourinary cancer - 1 Dec 2024

Maddah Mohammad Moein, Hedayatizadeh-Omran Akbar, Moosazadeh Mahmood, Alizadeh-Navaei Reza

Abstract excerpt

INTRODUCTION: Prostate cancer, 1 of the most common cancers in men, is influenced by age, genetics, race, and lifestyle. The TP53 gene, encoding the p53 protein crucial for cell cycle regulation and DNA repair, is frequently mutated in metastatic prostate cancers. These mutations impact prognosis and resistance to treatments, underscoring the role of genetic factors in disease progression and therapeutic...

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Identifiers

PMID: 39393313
DOI: 10.1016/j.clgc.2024.102226

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TP53

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