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Article

RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.

Blood - 1 Mar 2005

Schwäble Joachim, Choudhary Chunaram, Thiede Christian, Tickenbrock Lara, Sargin Bülent, Steur Claudia, Rehage Maike, Rudat Annika, Brandts Christian, Berdel Wolfgang E, Müller-Tidow Carsten, Serve Hubert

Abstract excerpt

Activating fetal liver tyrosine kinase 3 (Flt3) mutations represent the most common genetic aberrations in acute myeloid leukemia (AML). Most commonly, they occur as internal tandem duplications in the juxtamembrane domain (Flt3-ITD) that transform myeloid cells in vitro and in vivo and that indu...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15536149
DOI: 10.1182/blood-2004-03-0940

Genes

RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15536149-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.PMID 15536149Read ↗

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p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemiaSemantic proximity Read ↗

Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain.Semantic proximity Read ↗

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemiaSemantic proximity Read ↗

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