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Article

The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML.

Leukemia - 1 Mar 2022

Charlet Anne, Kappenstein Max, Keye Philip, Kläsener Kathrin, Endres Cornelia, Poggio Teresa, Gorantla Sivahari P, Kreutmair Stefanie, Sänger Jana, Illert Anna L, Miething Cornelius, Reth Michael, Duyster Justus, Rummelt Christoph, von Bubnoff Nikolas

Abstract excerpt

FLT3-ITD is the most predominant mutation in AML being expressed in about one-third of AML patients and is associated with a poor prognosis. Efforts to better understand FLT3-ITD downstream signaling to possibly improve therapy response are needed. We have previously described FLT3-ITD-dependent phosphorylation of CSF2RB, the common receptor beta chain of IL-3, IL-5, and GM-CSF, and therefore examined its...

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Identifiers

PMID: 34750506
DOI: 10.1038/s41375-021-01462-4
PMCID: PMC8885422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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