Article
[Mutations of growth factor receptor Flt3 in acute myeloid leukemia: transformation of myeloid cells by Ras-dependent and Ras-independent mechanisms].
Deutsche medizinische Wochenschrift (1946) - 18 Oct 2002
Müller-Tidow C, Steur C, Mizuki M, Schwäble J, Brandts C, Berdel W E, Serve H
Abstract excerpt
BACKGROUND AND OBJECTIVE: The tyrosine kinase receptor Flt3 mediates important functions in early hematopoietic progenitors. Recently mutations of a growth factor receptor have been identified in about 30 % of patients with acute myeloid leukemia (AML). These mutations are associated with a poor prognosis. In-vitro and animal data show their involvement in leukemic transformation. Experiments analyzing the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.