Article
Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma.
American journal of respiratory cell and molecular biology - 1 Jul 2015
Jiang Haihong, Xie Yan, Abel Peter W, Wolff Dennis W, Toews Myron L, Panettieri Reynold A, Casale Thomas B, Tu Yaping
Abstract excerpt
G protein-coupled receptors (GPCRs) are important regulators of cell functions in asthma. We recently reported that regulator of G-protein signaling (RGS) 2, a selective modulator of Gq-coupled GPCRs, is a key regulator of airway hyper-responsiveness (AHR), the pathophysiologic hallmark of asthma. Because RGS2 protein levels in airway cells were significantly lower in patients with asthma compared with patients...
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