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Article

Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.

Blood - 1 May 2005

Tickenbrock Lara, Schwäble Joachim, Wiedehage Markus, Steffen Björn, Sargin Bülent, Choudhary Chunaram, Brandts Christian, Berdel Wolfgang E, Müller-Tidow Carsten, Serve Hubert

Abstract excerpt

Activating Flt3 mutations occur in about 30% of patients with acute myeloid leukemia (AML), often as in-frame internal tandem duplication (ITD) at the juxtamembrane domain of the receptor. These mutations transform hematopoietic cell lines and primary mouse bone marrow. Here, we analyzed the interaction between oncogenic Flt3-ITD mutations and the Wingless-type (Wnt) signaling pathway in the myeloid progenitor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15650056
DOI: 10.1182/blood-2004-07-2924

Genes

TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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