Article
Mx1-cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype.
Genesis (New York, N.Y. : 2000) - 1 Mar 2013
Yang Shuying, Li Yi-Ping, Liu Tongjun, He Xiaoning, Yuan Xue, Li Chunyi, Cao Jay, Kim Yunjung
Abstract excerpt
Regulators of G-protein Signaling (Rgs) proteins are the members of a multigene family of GTPase-accelerating proteins (GAP) for the Galpha subunit of heterotrimeric G-proteins. Rgs proteins play critical roles in the regulation of G protein couple receptor (GPCR) signaling in normal physiology and human diseases such as cancer, heart diseases, and inflammation. Rgs12 is the largest protein of the Rgs protein...
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