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Article

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation

23 Oct 2018

Abstract excerpt

Fgr is a member of the Src family of nonreceptor tyrosine kinases, which are overexpressed and constitutively active in many human cancers. Fgr expression is restricted to myeloid hematopoietic cells and is markedly increased in a subset of bone marrow samples from patients with acute myeloid leukemia (AML). Here, we investigated the oncogenic potential of Fgr using Rat-2 fibroblasts that do not express the...

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PMID: 30352950
DOI: 10.1126/scisignal.aat5916

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