Article
Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation.
Leukemia - 1 Apr 2009
Perugini M, Kok C H, Brown A L, Wilkinson C R, Salerno D G, Young S M, Diakiw S M, Lewis I D, Gonda T J, D'Andrea R J
Abstract excerpt
The tumor suppressor Gadd45alpha was earlier shown to be a repressed target of sustained receptor-mediated ERK1/2 signaling. We have identified Gadd45alpha as a downregulated gene in response to constitutive signaling from two FLT3 mutants (FLT3-ITD and FLT3-TKD) commonly found in AML, and a leukemogenic GM-CSF receptor trans-membrane mutant (GMR-V449E). GADD45A mRNA downregulation is also associated with...
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