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Article

Processing of primary microRNAs by the Microprocessor complex.

Nature - 11 Nov 2004

Denli Ahmet M, Tops Bastiaan B J, Plasterk Ronald H A, Ketting René F, Hannon Gregory J

Abstract excerpt

Mature microRNAs (miRNAs) are generated via a two-step processing pathway to yield approximately 22-nucleotide small RNAs that regulate gene expression at the post-transcriptional level. Initial cleavage is catalysed by Drosha, a nuclease of the RNase III family, which acts on primary miRNA transcripts (pri-miRNAs) in the nucleus. Here we show that Drosha exists in a multiprotein complex, the Microprocessor, and...

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Identifiers

PMID: 15531879
DOI: 10.1038/nature03049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Processing of primary microRNAs by the Microprocessor complex.PMID 15531879Read ↗

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