Article
The insertion in the double-stranded RNA binding domain of human Drosha is important for its function.
Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Dec 2017
Zhang Xiaoxiao, Li Peng, Lin Jian, Huang Haochu, Yin Bin, Zeng Yan
Abstract excerpt
microRNAs (miRNAs) are first transcribed as long, primary transcripts, which are then processed by multiple enzymes and proteins to generate the single-stranded, approximately 22-nucleotide (nt)-long mature miRNAs. A critical step in animal miRNA biogenesis is the cleavage of primary miRNA transcripts (pri-miRNAs) to produce precursor miRNAs (pre-miRNAs) by the enzyme Drosha. How Drosha recognizes its substrates...
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