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Article

A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.

Molecular and cellular biology - 1 Feb 2009

Martin Raquel, Smibert Peter, Yalcin Abdullah, Tyler David M, Schäfer Ulrich, Tuschl Thomas, Lai Eric C

Abstract excerpt

Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route to generating mature approximately 22 nucleotide regulatory RNAs. We generated a null allele of Drosophila pasha, which encodes a double-stranded RNA-binding protein partner of the RNase III enzyme Drosha. Analysis of this mutant yielded stringent evidence that Pasha is essential for the...

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Identifiers

PMID: 19047376
DOI: 10.1128/MCB.01524-08
PMCID: PMC2630677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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