Article
RecA-dependent mutants in Escherichia coli reveal strategies to avoid chromosomal fragmentation.
Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2004
Kouzminova Elena A, Rotman Ella, Macomber Lee, Zhang Jian, Kuzminov Andrei
Abstract excerpt
RecA- and RecBC-catalyzed repair in eubacteria assembles chromosomes fragmented by double-strand breaks. We propose that recA mutants, being unable to repair fragmented chromosomes, depend on various strategies designed to avoid chromosomal fragmentation. To identify chromosomal fragmentation-avoidance strategies, we screened for Escherichia coli mutants synthetically inhibited in combination with recA...
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