Article
DNA Metabolism in Balance: Rapid Loss of a RecA-Based Hyperrec Phenotype.
PloS one - 1 Jan 2016
Bakhlanova Irina V, Dudkina Alexandra V, Wood Elizabeth A, Lanzov Vladislav A, Cox Michael M, Baitin Dmitry M
Abstract excerpt
The RecA recombinase of Escherichia coli has not evolved to optimally promote DNA pairing and strand exchange, the key processes of recombinational DNA repair. Instead, the recombinase function of RecA protein represents an evolutionary compromise between necessary levels of recombinational DNA repair and the potentially deleterious consequences of RecA functionality. A RecA variant, RecA D112R, promotes...
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