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Article

IL-10 regulates murine lupus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2002

Yin Zhinan, Bahtiyar Gul, Zhang Na, Liu Lanzhen, Zhu Ping, Robert Marie E, McNiff Jennifer, Madaio Michael P, Craft Joe

Abstract excerpt

MRL/MpJ-Tnfrsf6(lpr) (MRL/MpJ-Fas(lpr); MRL-Fas(lpr)) mice develop a spontaneous lupus syndrome closely resembling human systemic lupus erythematosus. To define the role of IL-10 in the regulation of murine lupus, IL-10 gene-deficient (IL-10(-/-)) MRL-Fas(lpr) (MRL-Fas(lpr) IL-10(-/-)) mice were generated and their disease phenotype was compared with littermates with one or two copies of an intact IL-10 locus...

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Source

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PMID: 12165544
DOI: 10.4049/jimmunol.169.4.2148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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