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Article

Accumulation of type IV collagen in dilated ER leads to apoptosis in Hsp47-knockout mouse embryos via induction of CHOP.

Journal of cell science - 15 Nov 2004

Marutani Toshihiro, Yamamoto Akitsugu, Nagai Naoko, Kubota Hiroshi, Nagata Kazuhiro

Abstract excerpt

Hsp47 is an endoplasmic reticulum (ER)-resident molecular chaperone that is specific for collagen. In Hsp47(-/-) mouse embryos at 9.5 days postcoitus (dpc), immunostaining indicated the absence of type IV collagen, but not of laminin and nidogen-1, in the basement membrane (BM). Electron immunomi...

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Source

Identifiers

PMID: 15522896
DOI: 10.1242/jcs.01514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15522896-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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