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Article

The Invalidation of HspB1 Gene in Mouse Alters the Ultrastructural Phenotype of Muscles.

PloS one - 1 Jan 2016

Kammoun Malek, Picard Brigitte, Astruc Thierry, Gagaoua Mohammed, Aubert Denise, Bonnet Muriel, Blanquet Véronique, Cassar-Malek Isabelle

Abstract excerpt

Even though abundance of Hsp27 is the highest in skeletal muscle, the relationships between the expression of HspB1 (encoding Hsp27) and muscle characteristics are not fully understood. In this study, we have analysed the effect of Hsp27 inactivation on mouse development and phenotype. We generated a mouse strain devoid of Hsp27 protein by homologous recombination of the HspB1 gene. The HspB1-/- mouse was viable...

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Identifiers

PMID: 27512988
DOI: 10.1371/journal.pone.0158644
PMCID: PMC4981447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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