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Article

Biology of Hsp47 (Serpin H1), a collagen-specific molecular chaperone.

Seminars in cell & developmental biology - 1 Feb 2017

Ito Shinya, Nagata Kazuhiro

Abstract excerpt

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum (ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the SERPINH1 gene, belongs to the serpin family and has the serpin fold; however, it has no serine protease inhibitory activity. Hsp47 transiently binds to procollagen in the ER, dissociates in the cis-Golgi or ER-Golgi intermediate...

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Identifiers

PMID: 27838364
DOI: 10.1016/j.semcdb.2016.11.005

Genes

SERPINH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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