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Article

Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.

American journal of respiratory cell and molecular biology - 1 Apr 2014

Mohamed Belal A, Barakat Amal Z, Held Torsten, Elkenani Manar, Mühlfeld Christian, Männer Jörg, Adham Ibrahim M

Abstract excerpt

Heat shock proteins HSPA4L and HSPA4 are closely related members of the HSP110 family and act as cochaperones. We generated Hspa4l(-/-)Hspa4(-/-) mice to investigate a functional complementarity between HSPA4L and HSPA4 during embryonic development. Hspa4l(-/-)Hspa4(-/-) embryos exhibited marked pulmonary hypoplasia and neonatal death. Compared with lungs of wild-type, Hspa4l(-/-), and Hspa4(-/-) embryos,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23980576
DOI: 10.1165/rcmb.2013-0132OC

Genes

HSPA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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