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Article

Essential role of synoviolin in embryogenesis.

The Journal of biological chemistry - 4 Mar 2005

Yagishita Naoko, Ohneda Kinuko, Amano Tetsuya, Yamasaki Satoshi, Sugiura Akiko, Tsuchimochi Kaneyuki, Shin Hiroshi, Kawahara Ko-Ichi, Ohneda Osamu, Ohta Tomohiko, Tanaka Sakae, Yamamoto Masayuki, Maruyama Ikuro, Nishioka Kusuki, Fukamizu Akiyoshi, Nakajima Toshihiro

Abstract excerpt

We recently reported the importance of Synoviolin in quality control of proteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) system and its involvement in the pathogenesis of arthropathy through its anti-apoptotic effect. For further understanding of the role of Synoviolin in vivo, we generated in this study synoviolin-deficient (syno(-/-)) mice by genetargeted disruption. Strikingly, all...

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PMID: 15611074
DOI: 10.1074/jbc.M410863200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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