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Article

Site-1 protease is essential for endochondral bone formation in mice.

The Journal of cell biology - 19 Nov 2007

Patra Debabrata, Xing Xiaoyun, Davies Sherri, Bryan Jennifer, Franz Carl, Hunziker Ernst B, Sandell Linda J

Abstract excerpt

Site-1 protease (S1P) has an essential function in the conversion of latent, membrane-bound transcription factors to their free, active form. In mammals, abundant expression of S1P in chondrocytes suggests an involvement in chondrocyte function. To determine the requirement of S1P in cartilage and bone development, we have created cartilage-specific S1P knockout mice (S1P(cko)). S1P(cko) mice exhibit...

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Identifiers

PMID: 18025304
DOI: 10.1083/jcb.200708092
PMCID: PMC2080931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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